Two anti-inflammatory drugs have been prescribed for both humans and animals to inhibit a key enzyme i.e. M-pro enzyme that causes the reproduction of coronavirus.
The novel coronavirus that causes the disease COVID-19 has been on the face of the earth for too long now, without any vaccine or medicine to contain and control it. This disease has caused 360,308 deaths among the confirmed 5,808,946 positive cases. When the entire world is praying for an end to this unprecedented disaster, it just keeps increasing and seems to be never-ending.
But this deep darkness that hovered over us for long, now sees a little light as the study that was published on International Journal of Molecular Sciences gave us an insight on the two inflammatory drugs where one drug would be for humans and the other for animals, which may inhibit the key enzyme in the replication and reproduction of the coronavirus that causes the disease COVID-19. The study also mentioned the usage of the many computer techniques that were used to analyze 6,466 drugs for both humans and animals from which 7 drugs were found to have the capability to inhibit the enzyme.
Researchers from the Rovira University in Spain assessed whether the drugs could be used to inhibit the main protein that causes the virus enzyme, which is the protease that plays the major essential role in the replication of the virus cells.
The two drugs:
Through the study done by researchers, the two drugs that have been selected to test their ability to inhibit the key enzyme are;
- Carprofen
- Celecoxib
These drugs could inhibit the key enzyme that is responsible for transcriptions and replication of the virus caused by SARS-CoV-2. Finding which drug that would inhibit the activity of the enzyme completely is the main step in finding a vaccine, to end the spread of the virus.
At the same point of time, researchers from Penn State of College and engineering are working on a Quantum machine learning model for the drug discovery of COVID-19. Quantum machine learning involves a combination of Quantum physics and Machine learning. They found that existing model of drug discovery process requires 5 to 10 years and billions of dollars to bring the vaccine to the market, where quantum machine learning makes the process fast and will be more economical. Using high performing Supercomputers and Artificial Intelligence tools, billions of chemical compound can be identified within a short period of time. The advancements in Big data and AI may help the researchers to make the best result soon.
Know more: AI in diagnosing COVID-19
